Liver-eye axis in metabolic syndrome: integrated evidence from mendelian randomization, single-cell sequencing, and clinical sample validation - Takeaways - MDSpire
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The Connection Between Liver and Eye Health in Metabolic Syndrome: Comprehensive Insights from Mendelian Randomization, Single-Cell Sequencing, and Clinical Sample Analysis

  • By

  • Tian-Hao Yuan

  • Yi-Fan Fang

  • Guo-Heng Zhang

  • Hao-Rui Zhang

  • Zi-Yi Zhou

  • Zhen-Sheng Yue

  • Bei Li

  • Lin Wang

  • Yu-Sheng Wang

  • Guo-Rui Dou

  • September 9, 2026

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  • 1

    NAFLD is causally linked to an increased risk of developing diabetic retinopathy, particularly in early non-proliferative stages.

  • 2

    The study identified LTB as a key mediator protein in the association between NAFLD and diabetic retinopathy.

  • 3

    Higher levels of LTB protein were found in the serum, aqueous humor, and vitreous humor of NAFLD patients with diabetic retinopathy.

  • 4

    The research utilized a multistage Mendelian randomization framework to assess the causal relationship between NAFLD and DR.

  • 5

    Single-cell transcriptome sequencing confirmed increased LTB gene expression in T cells and B cells in NAFLD model mice.

Original Source(s)

Liver-eye axis in metabolic syndrome: integrated evidence from mendelian randomization, single-cell sequencing, and clinical sample validation

  • by Tian-Hao Yuan, Yi-Fan Fang, Guo-Heng Zhang, Hao-Rui Zhang, Zi-Yi Zhou, Zhen-Sheng Yue, Bei Li, Lin Wang, Yu-Sheng Wang, Guo-Rui Dou

  • September 9, 2026

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