Spatiotemporal analysis of Crohn’s disease reveals PECAM2 signaling at the basis of the inflammation-to-fibrosis transition - Takeaways - MDSpire

Spatiotemporal analysis of Crohn’s disease reveals PECAM2 signaling at the basis of the inflammation-to-fibrosis transition

  • By

  • Luca Massimino

  • Tommaso Lorenzo Parigi

  • Matteo Riva

  • Sabrina Nicolò

  • Carmela Errico

  • Salvatore Spanò

  • Sara Mino

  • Mattia Bugatti

  • Alice Frontali

  • Federico Scarfò

  • Andrea Vignali

  • Andrea Municchi

  • Vincenzo Villanacci

  • Luca Albarello

  • Maurilio Ponzoni

  • Virginia Solitano

  • Alberto Malesci

  • Vipul Jairath

  • Laurent Peyrin-Biroulet

  • Pierpaolo Sileri

  • Silvio Danese

  • Federica Ungaro

  • July 18, 2025

  • 0 min

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  • 1

    Crohn's disease is a chronic inflammatory bowel condition that often leads to fibrotic strictures, requiring surgical intervention due to a lack of effective medical treatments.

  • 2

    The study utilized spatial transcriptomics and single-cell RNA sequencing to explore the transition from inflammation to fibrosis in Crohn's disease.

  • 3

    PECAM2 signaling was identified as a critical factor in the development of fibrosis, driven by interactions with CD38 in the mesenchymal compartment.

  • 4

    Inhibition of CD38 signaling significantly reduced colitis symptoms and colon thickening in a mouse model, suggesting a potential therapeutic target.

  • 5

    The findings highlight the importance of integrating advanced technologies like spatial transcriptomics to understand Crohn's disease pathogenesis and identify new treatment strategies.

Original Source(s)

Spatiotemporal analysis of Crohn’s disease reveals PECAM2 signaling at the basis of the inflammation-to-fibrosis transition

  • by Luca Massimino, Tommaso Lorenzo Parigi, Matteo Riva, Sabrina Nicolò, Carmela Errico, Salvatore Spanò, Sara Mino, Mattia Bugatti, Alice Frontali, Federico Scarfò, Andrea Vignali, Andrea Municchi, Vincenzo Villanacci, Luca Albarello, Maurilio Ponzoni, Virginia Solitano, Alberto Malesci, Vipul Jairath, Laurent Peyrin-Biroulet, Pierpaolo Sileri, Silvio Danese, Federica Ungaro

  • July 18, 2025

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