Efficacies of Sequenced Monotherapies of Mycobacterium avium Lung Infection in Mouse - Takeaways - MDSpire

Efficacies of Sequenced Monotherapies of Mycobacterium avium Lung Infection in Mouse

  • By

  • Ruth A Howe

  • Binayak Rimal

  • Jay Khandelwal

  • Chandra M Panthi

  • Gyanu Lamichhane

  • December 19, 2025

  • 0 min

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  • 1

    Nontuberculous mycobacterial infections, particularly Mycobacterium avium, are rising and now exceed tuberculosis incidence in several countries.

  • 2

    Current treatment guidelines for M. avium recommend multidrug regimens, but these are limited by toxicity, poor adherence, and low cure rates.

  • 3

    Sequential monotherapy using clarithromycin, bedaquiline, and clofazimine achieved similar bacterial burden reductions as standard multidrug therapy.

  • 4

    No increase in minimum inhibitory concentrations was observed during sequential monotherapy, indicating no selection for resistant clones.

  • 5

    The findings support further investigation of sequential monotherapy as a potentially more tolerable alternative to current triple-agent regimens.

Original Source(s)

Efficacies of Sequenced Monotherapies of Mycobacterium avium Lung Infection in Mouse

  • by Ruth A Howe, Binayak Rimal, Jay Khandelwal, Chandra M Panthi, Gyanu Lamichhane

  • December 19, 2025

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