Photon-counting CT-derived hepatic extracellular volume quantification for noninvasive risk stratification of clinically significant portal hypertension (CSPH): a prospective cohort study - Takeaways - MDSpire

Photon-counting CT-derived hepatic extracellular volume quantification for noninvasive risk stratification of clinically significant portal hypertension (CSPH): a prospective cohort study

  • By

  • Tatjana Dell

  • Verena Tischler

  • Dario Zocholl

  • Narine Mesropyan

  • Alice Margarida Jacob

  • Johannes Chang

  • Bernhard Schmidt

  • Claus Christian Pieper

  • Alexander Isaak

  • Patrick Kupczyk

  • Carsten Meyer

  • Julian Luetkens

  • Christian Strassburg

  • Christian Jansen

  • Daniel Kuetting

  • December 23, 2025

  • 0 min

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  • 1

    Chronic liver disease and cirrhosis are major global health issues, with significant mortality linked to HCV, HBV, and increasing metabolic liver diseases.

  • 2

    Clinically significant portal hypertension (CSPH) in compensated advanced chronic liver disease (cACLD) greatly increases the risk of severe complications.

  • 3

    Current CSPH diagnosis relies on invasive hepatic venous pressure gradient measurement, prompting the need for noninvasive assessment methods.

  • 4

    Photon-counting CT (PCCT) offers a promising approach for quantifying hepatic extracellular volume (ECV), potentially improving CSPH risk stratification.

  • 5

    This study evaluates the effectiveness of PCCT-derived ECV in stratifying CSPH risk alongside established noninvasive liver disease assessment techniques.

Original Source(s)

Photon-counting CT-derived hepatic extracellular volume quantification for noninvasive risk stratification of clinically significant portal hypertension (CSPH): a prospective cohort study

  • by Tatjana Dell, Verena Tischler, Dario Zocholl, Narine Mesropyan, Alice Margarida Jacob, Johannes Chang, Bernhard Schmidt, Claus Christian Pieper, Alexander Isaak, Patrick Kupczyk, Carsten Meyer, Julian Luetkens, Christian Strassburg, Christian Jansen, Daniel Kuetting

  • December 23, 2025

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