Polystyrene nanoplastics promotes inflammation and aging in young mice through the oral-gut microbiome axis - Takeaways - MDSpire

Polystyrene nanoplastics promotes inflammation and aging in young mice through the oral-gut microbiome axis

  • By

  • Ying Wang

  • Chunli Dong

  • Yi Xiao

  • May 28, 2026

  • 0 min

Share

  • 1

    Polystyrene nanoplastics (PS-NPs) disrupt the oral-gut microbiota axis, leading to inflammation and accelerated aging in young mice.

  • 2

    Exposure to PS-NPs significantly increases cellular senescence markers p21Cip1/Waf and p16Ink4a in the lungs and liver of young mice.

  • 3

    PS-NPs promote the release of inflammatory cytokines IL-1β, IL-6, and TNF-α by modulating the p38 MAPK signaling pathway.

  • 4

    16S rRNA sequencing reveals that PS-NPs exposure causes dysbiosis in oral and intestinal microbiota, altering microbial diversity.

  • 5

    The study provides insights into the toxicity of nanoplastics and suggests potential strategies for mitigating their health impacts.

Original Source(s)

Polystyrene nanoplastics promotes inflammation and aging in young mice through the oral-gut microbiome axis

  • by Ying Wang, Chunli Dong, Yi Xiao

  • May 28, 2026

Related Content

An interpretable machine learning model for predicting acute respiratory distress syndrome in critically ill patients with acute pancreatitis: A multicenter retrospective study

The life cycle of tertiary lymphoid structures in pancreatic cancer—a window of opportunity for immunotherapy

BFJPM ameliorates OVA-induced food allergy in a murine model accompanied by gut microbiota remodeling