Effects of exercise training on frailty, cardiorespiratory fitness, and lower limb function in non-dialysis chronic kidney disease: a systematic review and meta-analysis - Takeaways - MDSpire

Impact of Exercise Interventions on Frailty, Cardiorespiratory Fitness, and Lower Limb Function in Patients with Non-Dialysis Chronic Kidney Disease: A Systematic Review and Meta-Analysis

  • By

  • Sujie Yang

  • Fan Zhang

  • Xueling Li

  • Wen Zhu

  • Qiuye Chen

  • Yifei Zhong

  • Xianwen Zhang

  • July 20, 2026

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  • 1

    Eighteen randomized controlled trials involving 938 participants were included in the systematic review and meta-analysis.

  • 2

    Exercise interventions significantly improved walking speed and reduced fatigue in patients with non-dialysis chronic kidney disease.

  • 3

    Overall cardiorespiratory fitness and lower limb function were significantly enhanced through exercise interventions in the study population.

  • 4

    Outcomes for absolute body weight, handgrip strength, and general physical activity levels did not show statistical significance.

  • 5

    The systematic review aims to provide a detailed analysis of exercise effects on frailty, cardiorespiratory fitness, and lower limb function in NDD-CKD patients.

Original Source(s)

Effects of exercise training on frailty, cardiorespiratory fitness, and lower limb function in non-dialysis chronic kidney disease: a systematic review and meta-analysis

  • by Sujie Yang, Fan Zhang, Xueling Li, Wen Zhu, Qiuye Chen, Yifei Zhong, Xianwen Zhang

  • July 20, 2026

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