The combined use of in vivo confocal microscopy and optical coherence tomography in monitoring corneal infections - Takeaways - MDSpire

The combined use of in vivo confocal microscopy and optical coherence tomography in monitoring corneal infections

  • By

  • Farida Omar ElZawahry

  • Sarah Donatelli

  • Mario Nubile

  • Prity Sahay

  • Dalia G. Said

  • Harminder S. Dua

  • June 9, 2026

  • 0 min

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  • 1

    Infectious keratitis (IK) is a leading cause of blindness, characterized by acute ocular pain, decreased vision, and corneal ulceration.

  • 2

    Slit lamp microscopy and corneal scrape cultures are traditional diagnostic tools for IK, but imaging modalities like OCT and IVCM offer additional insights.

  • 3

    OCT provides high-magnification, cross-sectional images but is limited by poor imaging through scars and dense infiltrates.

  • 4

    IVCM allows cellular-level examination of corneal structures and can visualize invading organisms with high sensitivity and specificity.

  • 5

    This study evaluated IVCM and AS-OCT in 35 patients with severe IK to correlate imaging features for diagnosis and treatment monitoring.

Original Source(s)

The combined use of in vivo confocal microscopy and optical coherence tomography in monitoring corneal infections

  • by Farida Omar ElZawahry, Sarah Donatelli, Mario Nubile, Prity Sahay, Dalia G. Said, Harminder S. Dua

  • June 9, 2026

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