BFJPM ameliorates OVA-induced food allergy in a murine model accompanied by gut microbiota remodeling - Takeaways - MDSpire

BFJPM ameliorates OVA-induced food allergy in a murine model accompanied by gut microbiota remodeling

  • By

  • Xue Yang

  • Huiyi Peng

  • Rao Hu

  • Yifan Li

  • Ping Jiang

  • May 28, 2026

  • 0 min

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  • 1

    BufeiJianpi Mixture (BFJPM) effectively reduced food allergy symptoms and serum IgE levels in an OVA-induced murine model.

  • 2

    BFJPM improved the V/C ratio of the small intestinal mucosa in food allergy mice, indicating enhanced intestinal health.

  • 3

    Gut microbiota analysis revealed significant changes in composition, with increased richness and alterations in community structure due to BFJPM.

  • 4

    Saccharopolyspora was identified as a key genus associated with BFJPM treatment, showing a negative correlation with serum IgE levels.

  • 5

    Network pharmacology highlighted IL6, TNF, and IL10 as major targets of BFJPM, linking its effects to gut microbiota and food allergy mechanisms.

Original Source(s)

BFJPM ameliorates OVA-induced food allergy in a murine model accompanied by gut microbiota remodeling

  • by Xue Yang, Huiyi Peng, Rao Hu, Yifan Li, Ping Jiang

  • May 28, 2026

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