A study found an inverted U-shaped relationship between weekday sleep duration and insulin sensitivity, peaking at approximately 7.3 hours.
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Shorter and longer sleep durations were linked to lower insulin sensitivity, with each additional hour of sleep improving eGDR in those sleeping less than 7.32 hours.
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Moderate weekend catch-up sleep (WCS) improved metabolic markers for those with shorter weekday sleep, while excessive WCS did not show significant benefits.
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Subgroup analyses revealed that longer sleep duration negatively impacted insulin sensitivity particularly in women, adults aged 40-59, and individuals with obesity.
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The study's cross-sectional design limits causal inference, and self-reported sleep duration may introduce recall bias affecting the findings.
Mendelian randomization analyses linked higher birthweight with greater mid-childhood height but the connection could reflect genetic factors related to skeletal growth.
