Preclinical translational screening of palladium(II)-porphyrin photosensitizers across human and Oncopig bladder cancer cell lines - Takeaways - MDSpire

Preclinical translational screening of palladium(II)-porphyrin photosensitizers across human and Oncopig bladder cancer cell lines

  • By

  • Valentina G. Ferreira

  • Maria Eduarda Ehlert

  • Bruna S. Pacheco

  • Fernanda S. S. Souza

  • Isadora Tisoco

  • Lucas Damé Simões

  • Bernardo A. Iglesias

  • Claudia Ó. Pessoa

  • Fabiana K. Seixas

  • Maria Lucia Z. Dagli

  • Laurie A. Rund

  • Kyle M. Schachtschneider

  • Lawrence B. Schook

  • Tiago Veiras Collares

  • July 9, 2026

  • 0 min

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  • 1

    Bladder cancer is a prevalent malignancy with high recurrence rates and limited long-term response to conventional therapies.

  • 2

    Oncopig-derived bladder cancer models closely mimic human disease, providing a relevant platform for preclinical therapeutic evaluation.

  • 3

    Three palladium(II)-porphyrins were screened in vitro, showing light-dependent cytotoxicity with minimal dark toxicity in bladder cancer cell lines.

  • 4

    3-Pd(PPh3) and 3-Pd(dppf) exhibited potent photodynamic activity, while 3-Pd(PEPSI) showed lower potency across tested cell lines.

  • 5

    The study supports the use of Oncopig models for early screening of photosensitizers before advancing to large-animal studies.

Original Source(s)

Preclinical translational screening of palladium(II)-porphyrin photosensitizers across human and Oncopig bladder cancer cell lines

  • by Valentina G. Ferreira, Maria Eduarda Ehlert, Bruna S. Pacheco, Fernanda S. S. Souza, Isadora Tisoco, Lucas Damé Simões, Bernardo A. Iglesias, Claudia Ó. Pessoa, Fabiana K. Seixas, Maria Lucia Z. Dagli, Laurie A. Rund, Kyle M. Schachtschneider, Lawrence B. Schook, Tiago Veiras Collares

  • July 9, 2026

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