PSMA-PET/CT-based salvage elective nodal radiotherapy for lymph node recurrence following radical prostatectomy - Takeaways - MDSpire

PSMA-PET/CT-based salvage elective nodal radiotherapy for lymph node recurrence following radical prostatectomy

  • By

  • Samuel M. Vorbach

  • Hannah Rittmayer

  • Thomas Seppi

  • Bernhard Nilica

  • Mona Kafka

  • Ute Ganswindt

  • September 24, 2025

  • 0 min

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  • 1

    Prostate cancer is the most common malignancy in men in Europe, with biochemical recurrence occurring in about one third of patients after radical prostatectomy.

  • 2

    PSMA-PET/CT is a highly sensitive imaging modality for detecting local recurrence and metastasis in patients with biochemical recurrence after prostate surgery.

  • 3

    The PEACE V-STORM trial suggests that elective nodal radiotherapy may provide better biochemical recurrence-free survival than metastasis-directed therapy.

  • 4

    A retrospective analysis of 76 patients treated with PSMA-PET/CT-based salvage elective nodal radiotherapy showed promising outcomes in biochemical recurrence-free survival.

  • 5

    Androgen deprivation therapy is recommended for patients undergoing salvage elective nodal radiotherapy, tailored to individual patient needs and preferences.

Original Source(s)

PSMA-PET/CT-based salvage elective nodal radiotherapy for lymph node recurrence following radical prostatectomy

  • by Samuel M. Vorbach, Hannah Rittmayer, Thomas Seppi, Bernhard Nilica, Mona Kafka, Ute Ganswindt

  • September 24, 2025

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