Transmission of Mycobacterium tuberculosis in Child and Adolescent Contacts of Pulmonary Tuberculosis Patients in Brazil: A Multi-Center Prospective Cohort Analysis - Takeaways - MDSpire

Transmission of Mycobacterium tuberculosis in Child and Adolescent Contacts of Pulmonary Tuberculosis Patients in Brazil: A Multi-Center Prospective Cohort Analysis

  • By

  • Luciana Sobral

  • María B. Arriaga

  • Alexandra B. Souza

  • Beatriz Barreto-Duarte

  • Beatriz S. Garcia-Rosa

  • Catarina D. Fernandes

  • Artur T. L. Queiroz

  • Michael S. Rocha

  • Aline Benjamin

  • Adriana S. R. Moreira

  • Jamile G. de Oliveira

  • Anna Cristina C. Carvalho

  • Renata Spener-Gomes

  • Marina C. Figueiredo

  • Solange Cavalcante

  • Betina Durovni

  • José R. Lapa-e-Silva

  • Afrânio L. Kritski

  • Valeria C. Rolla

  • Timothy R. Sterling

  • Marcelo Cordeiro-Santos

  • Mariana Araújo-Pereira

  • Bruno B. Andrade

  • December 22, 2025

  • 0 min

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  • 1

    Tuberculosis (TB) significantly affects children and adolescents in Brazil, with 67,497 cases reported from 2015 to 2023.

  • 2

    Children under 5 years are particularly vulnerable, with TB cases increasing from 899 in 2015 to 1,469 in 2023.

  • 3

    Recent exposure to infectious TB cases, especially within households, greatly increases the risk of TB infection in children.

  • 4

    The study utilized IGRA testing to evaluate Mycobacterium tuberculosis transmission among child and adolescent contacts of TB patients.

  • 5

    Preventive treatment for TB is recommended for close contacts with positive IGRA results or those under 5 years of age.

Original Source(s)

Transmission of Mycobacterium tuberculosis in Child and Adolescent Contacts of Pulmonary Tuberculosis Patients in Brazil: A Multi-Center Prospective Cohort Analysis

  • by Luciana Sobral, María B. Arriaga, Alexandra B. Souza, Beatriz Barreto-Duarte, Beatriz S. Garcia-Rosa, Catarina D. Fernandes, Artur T. L. Queiroz, Michael S. Rocha, Aline Benjamin, Adriana S. R. Moreira, Jamile G. de Oliveira, Anna Cristina C. Carvalho, Renata Spener-Gomes, Marina C. Figueiredo, Solange Cavalcante, Betina Durovni, José R. Lapa-e-Silva, Afrânio L. Kritski, Valeria C. Rolla, Timothy R. Sterling, Marcelo Cordeiro-Santos, Mariana Araújo-Pereira, Bruno B. Andrade

  • December 22, 2025

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