Early screening and post-treatment chronic endometritis in subsequent frozen embryo transfer cycles among women with first implantation failure: a retrospective cohort study - Takeaways - MDSpire

Early screening and post-treatment chronic endometritis in subsequent frozen embryo transfer cycles among women with first implantation failure: a retrospective cohort study

  • By

  • Longlong Wei

  • Yixuan Zhang

  • Shuna Wang

  • Siyue Xu

  • Weiran Hu

  • July 8, 2026

  • 0 min

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  • 1

    Chronic endometritis (CE) was identified in 16.8% of women experiencing first implantation failure (FIF) after IVF/ICSI.

  • 2

    The cure rate for women with CE after two courses of standardized antibiotic treatment was 89.1%.

  • 3

    Women with persistent chronic endometritis (PCE) had significantly lower live birth rates compared to those with CD138-positive plasma cells ≤4/HPF.

  • 4

    Pregnancy outcomes for women with CE achieving histological remission were comparable to those with CD138-positive plasma cells ≤4/HPF.

  • 5

    The study highlights the need for early evaluation of endometrial factors in women with FIF to potentially improve reproductive outcomes.

Original Source(s)

Early screening and post-treatment chronic endometritis in subsequent frozen embryo transfer cycles among women with first implantation failure: a retrospective cohort study

  • by Longlong Wei, Yixuan Zhang, Shuna Wang, Siyue Xu, Weiran Hu

  • July 8, 2026

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