The Hidden Diversity of Amyloid Plaques
A multimodal MSI approach reveals how plaque-associated lipid signatures differ across brain regions in Alzheimer’s disease
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By
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Henry Thomas
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April 7, 2026
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1
Amyloid plaques disrupt the local lipid environment in the brain, with variations observed across different brain regions.
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A multimodal mass spectrometry imaging framework was developed to analyze plaque-associated lipids at high spatial resolution.
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The study identified distinct lipid signatures linked to metabolic pathways, revealing regional heterogeneity in lipid profiles.
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Machine learning models accurately predicted the brain region of plaques based on their lipid composition.
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Lipid dysregulation in Alzheimer's disease is complex and remains poorly understood, despite being recognized for over a century.
