Probiotics and Risk of Death, Necrotizing Enterocolitis, and Sepsis in Very Preterm Infants - Takeaways - MDSpire
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Impact of Probiotics on Mortality, Necrotizing Enterocolitis, and Sepsis in Extremely Preterm Infants

  • By

  • Ayoub Mitha

  • Sofia Söderquist Kruth

  • Emma Sinervo

  • Magnus Domellöf

  • Björn Brindefalk

  • Thomas Abrahamsson

  • Stefan Johansson

  • Alexander Rakow

  • September 23, 2026

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  • 1

    Probiotic supplementation is being investigated to reduce necrotizing enterocolitis (NEC) incidence in preterm infants due to intestinal immaturity and dysbiosis.

  • 2

    Certain probiotic strains may lower NEC incidence and all-cause mortality among preterm infants, but findings vary due to differences in study design.

  • 3

    Probiotic use in neonatal units varies globally, influenced by product quality, safety concerns, and clinical practice guidelines.

  • 4

    In 2020, Sweden implemented a national guideline for probiotic supplementation in very preterm infants, based on European recommendations.

  • 5

    The study assessed associations between probiotic supplementation and outcomes like death, NEC, and sepsis using data from the Swedish Neonatal Quality Register.

Original Source(s)

Probiotics and Risk of Death, Necrotizing Enterocolitis, and Sepsis in Very Preterm Infants

  • by Ayoub Mitha, Sofia Söderquist Kruth, Emma Sinervo, Magnus Domellöf, Björn Brindefalk, Thomas Abrahamsson, Stefan Johansson, Alexander Rakow

  • September 23, 2026

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