IRGM genetic variants associate with tuberculosis disease in a European population - Takeaways - MDSpire
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Genetic Variants in IRGM Linked to Tuberculosis Susceptibility in a European Cohort

  • By

  • Tonino Alonzi

  • Assunta Navarra

  • Razaq Durodoye

  • Jacquelaine Bartlett

  • Anna Rosa Garbuglia

  • Daniela Lapa

  • Valentina Vanini

  • Gilda Cuzzi

  • Andrea Capri

  • Annapaola Santoro

  • Vincenzo Puro

  • Enrico Girardi

  • Gina Gualano

  • Fabrizio Palmieri

  • Gian Maria Fimia

  • Mauro Piacentini

  • Anurag Verma

  • Scott M. Williams

  • Giorgio Sirugo

  • Delia Goletti

  • September 7, 2026

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  • 1

    Tuberculosis affects more than 10 million people each year and caused approximately 1.25 million deaths in 2023.

  • 2

    IRGM plays a central role in autophagy initiation and has been investigated as a host genetic factor that may influence tuberculosis susceptibility.

  • 3

    Previous studies have reported population-specific associations between IRGM polymorphisms and tuberculosis susceptibility, with differing effects across ethnic groups.

  • 4

    This study evaluated 2 intronic IRGM SNPs, rs4958847 and rs72553867, individually and in combination, to determine whether they were associated with TB disease or TB infection in a European population.

  • 5

    Participants included patients with TB disease, individuals with TB infection, and TB-free controls, all residing in Italy at enrollment.

Original Source(s)

IRGM genetic variants associate with tuberculosis disease in a European population

  • by Tonino Alonzi, Assunta Navarra, Razaq Durodoye, Jacquelaine Bartlett, Anna Rosa Garbuglia, Daniela Lapa, Valentina Vanini, Gilda Cuzzi, Andrea Capri, Annapaola Santoro, Vincenzo Puro, Enrico Girardi, Gina Gualano, Fabrizio Palmieri, Gian Maria Fimia, Mauro Piacentini, Anurag Verma, Scott M. Williams, Giorgio Sirugo, Delia Goletti

  • September 7, 2026

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