Impact of low-level sex chromosome mosaicism (<10%) on clinical outcomes of first fresh embryo transfer: a propensity score-matched retrospective cohort study - Takeaways - MDSpire

Impact of low-level sex chromosome mosaicism (<10%) on clinical outcomes of first fresh embryo transfer: a propensity score-matched retrospective cohort study

  • By

  • Keng Feng

  • HaiWen Wei

  • YuDi Luo

  • DeRong Li

  • Xiang Li

  • Chun Yang

  • LiangYing Zhou

  • ShaYan Tan

  • LingLing Zhu

  • July 16, 2026

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  • 1

    This study analyzed 3,216 infertile patients undergoing their first ART cycle to assess the impact of low-level sex chromosome mosaicism on clinical outcomes.

  • 2

    After propensity score matching, no significant differences were found in live birth rates, clinical pregnancy rates, or early miscarriage rates between SCM and control groups.

  • 3

    Multivariable logistic regression indicated no independent association between SCM status and live birth or clinical pregnancy outcomes.

  • 4

    Female age was identified as a significant predictor of ART outcomes, with each additional year reducing live birth odds by 12.8%.

  • 5

    The findings suggest that low-level sex chromosome mosaicism does not significantly affect reproductive outcomes in the first fresh ART transfer cycle.

Original Source(s)

Impact of low-level sex chromosome mosaicism (<10%) on clinical outcomes of first fresh embryo transfer: a propensity score-matched retrospective cohort study

  • by Keng Feng, HaiWen Wei, YuDi Luo, DeRong Li, Xiang Li, Chun Yang, LiangYing Zhou, ShaYan Tan, LingLing Zhu

  • July 16, 2026

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