Risk of Post-COVID-19 Conditions Among Adolescents and Adults Who Received Nirmatrelvir-Ritonavir for Acute COVID-19: A Retrospective Cohort Study - Takeaways - MDSpire

Risk of Post-COVID-19 Conditions Among Adolescents and Adults Who Received Nirmatrelvir-Ritonavir for Acute COVID-19: A Retrospective Cohort Study

  • By

  • Alexandra F Dalton

  • Sarah Baca

  • Julia Raykin

  • Cria O Gregory

  • Tegan Boehmer

  • Emilia H Koumans

  • Priti R Patel

  • Pragna Patel

  • Sharon Saydah

  • September 16, 2025

  • 0 min

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  • 1

    Nirmatrelvir-ritonavir treatment for acute COVID-19 may reduce the risk of Post-COVID-19 Conditions (PCC) in adults aged 50-64 and ≥65 years.

  • 2

    The study analyzed real-world data from over 873,000 patients to evaluate the association between nirmatrelvir-ritonavir and PCC.

  • 3

    Treatment with nirmatrelvir-ritonavir showed minimal effect on PCC risk in high-risk adults aged 18-49 and no effect in adolescents aged 12-17.

  • 4

    PCC is characterized by lingering symptoms and conditions affecting multiple organ systems, impacting 6.9% of adults and 1.3% of children in the US.

  • 5

    The findings suggest considering outpatient nirmatrelvir-ritonavir treatment for mild to moderate COVID-19 to mitigate severe disease and PCC risk.

Original Source(s)

Risk of Post-COVID-19 Conditions Among Adolescents and Adults Who Received Nirmatrelvir-Ritonavir for Acute COVID-19: A Retrospective Cohort Study

  • by Alexandra F Dalton, Sarah Baca, Julia Raykin, Cria O Gregory, Tegan Boehmer, Emilia H Koumans, Priti R Patel, Pragna Patel, Sharon Saydah

  • September 16, 2025

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