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1
The immune system's understanding has evolved from self-nonself discrimination to broader models like the Damage Response Framework and the Discontinuity Model.
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2
Immune tolerance allows the immune system to manage foreign antigens, such as those from the microbiome, without generating an immune response.
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3
Disease from autoantigens and foreign antigens arises when the immune system is defective in critical components, leading to impaired immune competency.
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4
The immune system's primary role includes waste disposal, autophagy, and tissue repair, functioning effectively in asymptomatic individuals during pandemics.
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5
Self-nonself discrimination has been re-evaluated, revealing that both self and non-self antigens can induce immune responses under specific contexts.
