Calcium Channel Blockers and POAG Risk - Takeaways - MDSpire

Calcium Channel Blockers and POAG Risk

  • July 1, 2026

  • 3 min

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  • 1

    Calcium channel blockers (CCBs) may increase the risk of progression to severe primary open-angle glaucoma (POAG), according to a large retrospective cohort study.

  • 2

    The study analyzed data from over 7,400 patients with mild to moderate POAG, comparing those using CCBs to matched controls.

  • 3

    Dihydropyridine CCBs (dCCBs) users had a 67% higher relative risk of progression to severe POAG compared to controls.

  • 4

    Nondihydropyridine CCBs (ndCCBs) users showed more than a threefold increased risk of progression to severe POAG.

  • 5

    The study authors noted that their findings do not establish causation and highlighted several limitations in their research.

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