Correlation of Serological Biomarkers with Endoscopic Mucosal Recovery and Disease Activity in Inflammatory Bowel Disease Patients: A Retrospective Analysis

1

This study analyzed clinical data from 200 IBD patients and 100 healthy controls to assess serological markers related to mucosal healing.
2

CRP, TNF-α, ESR, and PLT levels were significantly elevated in IBD patients, while ALB levels were reduced compared to healthy controls.
3

In inactive IBD patients, levels of CRP, TNF-α, ESR, and PLT were lower, and ALB levels were higher compared to active patients.
4

The combined test AUC for serological markers in assessing mucosal healing in UC patients was 0.922, surpassing individual markers.
5

Serum levels of CRP, TNF-α, ALB, ESR, and PLT are associated with mucosal healing and inflammation in IBD patients.

Frontiers In Immunology

by Lu Zhou, Jinfu Dong, Yifan Chen, Yuying Zhou, Zhu Jin, Tianyi Xi, Wen Lu, Henghua Zhou
July 20, 2026

1