p53-associated regulation of COX17 enhances elesclomol-induced copper-associated cytotoxicity and suppresses gastric cancer growth - Takeaways - MDSpire

p53-associated regulation of COX17 enhances elesclomol-induced copper-associated cytotoxicity and suppresses gastric cancer growth

  • By

  • Qianling Li

  • Xiaoyin Dong

  • Yu Zhao

  • Yun Shen

  • Chenyang Yang

  • Yu Xi

  • June 15, 2026

  • 0 min

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  • 1

    COX17 enhances copper accumulation and increases sensitivity of gastric cancer cells to elesclomol-induced cytotoxicity.

  • 2

    p53 overexpression promotes COX17 expression, linking p53 signaling to copper metabolism in gastric cancer.

  • 3

    Elesclomol treatment with COX17 modulation results in altered expression of copper handling proteins SLC31A1 and ATP7A.

  • 4

    Conditioned media from elesclomol-treated COX17-overexpressing cells inhibits angiogenesis and increases oxidative stress in HUVECs.

  • 5

    In vivo studies show that elesclomol reduces tumor growth, with effects enhanced by COX17 overexpression and linked to increased copper accumulation.

Original Source(s)

p53-associated regulation of COX17 enhances elesclomol-induced copper-associated cytotoxicity and suppresses gastric cancer growth

  • by Qianling Li, Xiaoyin Dong, Yu Zhao, Yun Shen, Chenyang Yang, Yu Xi

  • June 15, 2026

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