Kimura disease presenting as a right lower limb soft tissue tumor: a case report - Takeaways - MDSpire

Kimura disease presenting as a right lower limb soft tissue tumor: a case report

  • By

  • Kun Hao

  • Feng Gao

  • June 22, 2026

  • 0 min

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  • 1

    Kimura disease (KD) is a rare chronic inflammatory disorder characterized by soft tissue masses, elevated eosinophil counts, and high serum IgE levels.

  • 2

    The case report details a 53-year-old male with a localized soft tissue mass in the right lower leg, exhibiting normal eosinophil count and serum IgE.

  • 3

    Histopathological examination revealed lymphocyte proliferation, eosinophilic infiltration, small vessel proliferation, and focal interstitial fibrosis, confirming KD.

  • 4

    Immunohistochemical analysis showed intratumoral vascular proliferation, distinguishing KD from other eosinophilic disorders like angiolymphoid hyperplasia.

  • 5

    The report emphasizes the importance of pathological examination in diagnosing atypical presentations of Kimura disease, particularly in extremities.

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