Uncommon Progression of BRAF/KRAS Wild-Type Colorectal Cancer: A Case Study of Cerebral Metastasis After Standard Treatment - Takeaways - MDSpire

Uncommon Progression of BRAF/KRAS Wild-Type Colorectal Cancer: A Case Study of Cerebral Metastasis After Standard Treatment

  • By

  • Nazmin Ahmed

  • Vishal K. Chavda

  • Mohammad Nazrul Hossain

  • April 24, 2026

  • 0 min

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  • 1

    Brain metastasis from colorectal cancer is rare, occurring in 1%-4% of cases, typically in advanced disease with aggressive molecular features.

  • 2

    The case study reports a 66-year-old woman with wild-type KRAS/BRAF colorectal cancer who developed brain metastasis after apparent systemic remission.

  • 3

    Molecular profiling revealed a microsatellite-stable tumor with low tumor mutational burden and a TP53 mutation, indicating a low-risk phenotype.

  • 4

    The patient underwent successful surgical resection of brain metastasis, challenging assumptions about CNS risk in molecularly favorable colorectal cancer.

  • 5

    This case highlights the need for individualized neurological surveillance strategies in colorectal cancer patients, even with low-risk molecular profiles.

Original Source(s)

Uncommon Progression of BRAF/KRAS Wild-Type Colorectal Cancer: A Case Study of Cerebral Metastasis After Standard Treatment

  • by Nazmin Ahmed, Vishal K. Chavda, Mohammad Nazrul Hossain

  • April 24, 2026

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