Plasma metabolomic signature of healthy lifestyle, structural brain reserve and risk of dementia - Takeaways - MDSpire

Plasma metabolomic signature of healthy lifestyle, structural brain reserve and risk of dementia

  • By

  • Fei Tian

  • Yuhua Wang

  • Zhengmin (Min) Qian

  • Shanshan Ran

  • Zilong Zhang

  • Chongjian Wang

  • Stephen Edward McMillin

  • Niraj R Chavan

  • Hualiang Lin

  • September 26, 2024

  • 0 min

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  • 1

    A metabolic signature indicative of a healthy lifestyle was identified in 136,628 dementia-free participants from the UK Biobank.

  • 2

    The metabolic signature was associated with a lower risk of all-cause dementia, Alzheimer's dementia, and vascular dementia.

  • 3

    Mendelian randomization indicated potential causal relationships between identified metabolites and dementia risk.

  • 4

    Structural brain reserve, particularly in regions like the hippocampus, mediated the relationship between metabolic signature and dementia risk.

  • 5

    Findings highlight the intricate connections between lifestyle, metabolism, and brain health in relation to dementia risk.

Original Source(s)

Plasma metabolomic signature of healthy lifestyle, structural brain reserve and risk of dementia

  • by Fei Tian, Yuhua Wang, Zhengmin (Min) Qian, Shanshan Ran, Zilong Zhang, Chongjian Wang, Stephen Edward McMillin, Niraj R Chavan, Hualiang Lin

  • September 26, 2024

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