Exerkines in heart failure: from molecular insights to clinical translation - Takeaways - MDSpire

Exerkines in heart failure: from molecular insights to clinical translation

  • By

  • Rodrigo Núñez-Cortés

  • Rubén López-Bueno

  • Joaquín Calatayud

  • October 16, 2025

  • 0 min

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  • 1

    Heart failure is characterized by exercise intolerance due to cardiac dysfunction and systemic abnormalities.

  • 2

    Exercise training activates signaling pathways that protect the myocardium and promote systemic adaptations in heart failure patients.

  • 3

    Exerkines, released during exercise, are emerging as therapeutic targets and biomarkers for cardiovascular disease.

  • 4

    Structured physical training significantly reduces pro-inflammatory cytokines IL-6 and TNF-α, correlating with improved cardiac function.

  • 5

    Future research should explore optimal exercise regimens and integrate biological, behavioral, and psychosocial factors for effective rehabilitation.

Original Source(s)

Exerkines in heart failure: from molecular insights to clinical translation

  • by Rodrigo Núñez-Cortés, Rubén López-Bueno, Joaquín Calatayud

  • October 16, 2025

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