Hydrocortisone for prevention or treatment of bronchopulmonary dysplasia: long-term neurodevelopmental safety and efficacy—a meta-analysis of randomized clinical trials - Takeaways - MDSpire

Hydrocortisone for prevention or treatment of bronchopulmonary dysplasia: long-term neurodevelopmental safety and efficacy—a meta-analysis of randomized clinical trials

  • By

  • Kawthar Ahmed Shehab

  • Rahaf Muslih N. Almatrafi

  • Ethar Ali

  • Yara Albargi

  • Sama Saabi

  • Halah Alhassan Aljohani

  • Rayan Nabil Almuhanna

  • Raghad Alnaami

  • Khalid Abdulrahman Almehery

  • Reema Safar Alamri

  • Sarah Ahmed A. Baqer

  • Shouq Naif Aloufi

  • Ahmed Elaraby

  • Bedah Mohammed Alnawfal

  • June 24, 2026

  • 0 min

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  • 1

    Hydrocortisone was compared with placebo in 17 randomized controlled trials involving 2,213 preterm infants to assess its efficacy in preventing bronchopulmonary dysplasia.

  • 2

    At 2 years, the composite outcome of death or neurodevelopmental impairment was 53.5% in the hydrocortisone group and 56.8% in the placebo group, showing no significant difference.

  • 3

    Hydrocortisone did not significantly affect mortality rates or neurodevelopmental impairment rates at 2 years compared to placebo.

  • 4

    Exploratory analyses indicated no significant reduction in death or bronchopulmonary dysplasia at 36 weeks postmenstrual age.

  • 5

    The findings suggest that hydrocortisone does not increase neurodevelopmental risk, but its use should be individualized based on specific clinical factors.

Original Source(s)

Hydrocortisone for prevention or treatment of bronchopulmonary dysplasia: long-term neurodevelopmental safety and efficacy—a meta-analysis of randomized clinical trials

  • by Kawthar Ahmed Shehab, Rahaf Muslih N. Almatrafi, Ethar Ali, Yara Albargi, Sama Saabi, Halah Alhassan Aljohani, Rayan Nabil Almuhanna, Raghad Alnaami, Khalid Abdulrahman Almehery, Reema Safar Alamri, Sarah Ahmed A. Baqer, Shouq Naif Aloufi, Ahmed Elaraby, Bedah Mohammed Alnawfal

  • June 24, 2026

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