Blood neurofilament light chain measurements in adults with CNS histiocytic neoplasms - Takeaways - MDSpire

Blood neurofilament light chain measurements in adults with CNS histiocytic neoplasms

  • By

  • Samantha A. Banks

  • Paul Decker

  • Eoin P. Flanagan

  • Anastasia Zekeridou

  • Ronald S. Go

  • Jithma P. Abeykoon

  • Gaurav Goyal

  • Jason R. Young

  • Matthew J. Koster

  • Robert Vassallo

  • Jay H. Ryu

  • Caroline J. Davidge-Pitts

  • Aishwarya Ravindran

  • Julio C. Sartori Valinotti

  • N. Nora Bennani

  • Mithun V. Shah

  • Karen L. Rech

  • Corrie R. Bach

  • Jeanette E. Eckel-Passow

  • W. Oliver Tobin

  • September 5, 2024

  • 0 min

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  • 1

    Histiocytic neoplasms are rare hematologic disorders that can significantly impact the central nervous system (CNS), leading to increased morbidity and mortality.

  • 2

    Neurofilament light chain (NfL) is a biomarker for axonal degeneration, showing potential for monitoring CNS disease activity in patients with histiocytic neoplasms.

  • 3

    Elevated NfL levels were significantly associated with CNS involvement and active CNS disease in patients with histiocytic neoplasms.

  • 4

    The study included 83 patients with various types of histiocytic neoplasms, with 51% diagnosed with Erdheim-Chester disease (ECD) and 28% with Langerhans cell histiocytosis (LCH).

  • 5

    BRAF mutations were present in 43% of patients tested, with a higher prevalence in those exhibiting CNS involvement compared to those without.

Original Source(s)

Blood neurofilament light chain measurements in adults with CNS histiocytic neoplasms

  • by Samantha A. Banks, Paul Decker, Eoin P. Flanagan, Anastasia Zekeridou, Ronald S. Go, Jithma P. Abeykoon, Gaurav Goyal, Jason R. Young, Matthew J. Koster, Robert Vassallo, Jay H. Ryu, Caroline J. Davidge-Pitts, Aishwarya Ravindran, Julio C. Sartori Valinotti, N. Nora Bennani, Mithun V. Shah, Karen L. Rech, Corrie R. Bach, Jeanette E. Eckel-Passow, W. Oliver Tobin

  • September 5, 2024

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