From risk factors to molecular targets: clinical associations and molecular docking insights into phthalate-associated diabetic retinopathy - Takeaways - MDSpire
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Identifying Risk Factors and Molecular Targets: Clinical Links and Molecular Docking Analysis of Phthalate-Related Diabetic Retinopathy

  • By

  • Zhiwei Xu

  • Shi Bai

  • Caidi He

  • Xiaobei Lv

  • Qin Li

  • Qile Mao

  • Haijian Wu

  • Peter Wang

  • May 13, 2026

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  • 1

    The study identifies novel risk factors for diabetic retinopathy (DR) using NHANES data and an independent clinical cohort.

  • 2

    Longer weekday outdoor time and higher serum vitamin D levels are associated with increased and decreased odds of DR, respectively.

  • 3

    Cataract presence is strongly linked to DR, while less electronic device use correlates with lower odds of developing the condition.

  • 4

    Urinary assessments show inverse associations between certain phthalates and DR, suggesting environmental exposure may influence DR risk.

  • 5

    Network toxicology analysis reveals 123 target genes related to DR, highlighting potential molecular pathways for further research.

Original Source(s)

From risk factors to molecular targets: clinical associations and molecular docking insights into phthalate-associated diabetic retinopathy

  • by Zhiwei Xu, Shi Bai, Caidi He, Xiaobei Lv, Qin Li, Qile Mao, Haijian Wu, Peter Wang

  • May 13, 2026

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