Analysis of the Frequency and Outcomes of Transformed Nodular Lymphocyte-Predominant Hodgkin Lymphoma in the United States: A Population-Based Study - Takeaways - MDSpire

Analysis of the Frequency and Outcomes of Transformed Nodular Lymphocyte-Predominant Hodgkin Lymphoma in the United States: A Population-Based Study

  • By

  • John L. Vaughn

  • Malak Munir

  • Ashley Cobb

  • Sravani Rimmalapudi

  • Narendranath Epperla

  • April 23, 2026

  • 0 min

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  • 1

    Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) has a low transformation rate to diffuse large B-cell lymphoma (DLBCL) at 2.59%.

  • 2

    Patients with transformed NLPHL (t-NLPHL) experience significantly worse survival outcomes compared to those with non-transformed NLPHL.

  • 3

    The 5-year relative survival rate for t-NLPHL patients is 88%, compared to 97% for non-transformed NLPHL patients.

  • 4

    Survival rates for t-NLPHL patients are better than those for de novo DLBCL, with a 5-year relative survival rate of 84%.

  • 5

    This study emphasizes the need for further research on the clinical implications of transformation in NLPHL.

Original Source(s)

Analysis of the Frequency and Outcomes of Transformed Nodular Lymphocyte-Predominant Hodgkin Lymphoma in the United States: A Population-Based Study

  • by John L. Vaughn, Malak Munir, Ashley Cobb, Sravani Rimmalapudi, Narendranath Epperla

  • April 23, 2026

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