Predicting CAR-T outcomes in R/R DLBCL: a multicenter real-world study of a 5-index model - Takeaways - MDSpire

Predicting CAR-T outcomes in R/R DLBCL: a multicenter real-world study of a 5-index model

  • By

  • Bin Xue

  • Huina Lu

  • Yifan Liu

  • Ying Lu

  • Wenjun Zhang

  • Bing Xiu

  • Xiu Luo

  • Li Wang

  • Wenbin Qian

  • Aibin Liang

  • Ping Li

  • June 16, 2026

  • 0 min

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  • 1

    The study validated a five-index prediction model for CD19 CAR-T therapy in Chinese patients with relapsed/refractory DLBCL.

  • 2

    The model incorporates double-expressor lymphoma status, TP53 alterations, ECOG performance status, bulky disease, and prior therapy lines.

  • 3

    The model demonstrated a C-index of 0.767, indicating strong predictive performance for overall response and survival outcomes.

  • 4

    Patients stratified by the model showed significant differences in progression-free survival and overall survival.

  • 5

    The findings support personalized treatment decisions for DLBCL patients undergoing CAR-T therapy in real-world settings.

Original Source(s)

Predicting CAR-T outcomes in R/R DLBCL: a multicenter real-world study of a 5-index model

  • by Bin Xue, Huina Lu, Yifan Liu, Ying Lu, Wenjun Zhang, Bing Xiu, Xiu Luo, Li Wang, Wenbin Qian, Aibin Liang, Ping Li

  • June 16, 2026

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