Effects of SOX10 on the proliferative, invasive, migratory, and epithelial–mesenchymal transition abilities of triple-negative breast cancer cells - Takeaways - MDSpire

Effects of SOX10 on the proliferative, invasive, migratory, and epithelial–mesenchymal transition abilities of triple-negative breast cancer cells

  • By

  • Shuai Wang

  • Linfang Jin

  • May 18, 2026

  • 0 min

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  • 1

    SOX10 significantly enhances proliferation, migration, and invasion in triple-negative breast cancer (TNBC) cells.

  • 2

    Knockdown of SOX10 markedly inhibits these malignant behaviors in TNBC cell lines.

  • 3

    SOX10 upregulates mesenchymal markers and Wnt/β-catenin pathway components while downregulating epithelial markers.

  • 4

    Wnt pathway activation reverses EMT suppression from SOX10 knockdown, while inhibition reduces EMT promotion from SOX10 overexpression.

  • 5

    The SOX10-Wnt/β-catenin axis may serve as a potential therapeutic target for TNBC.

Original Source(s)

Effects of SOX10 on the proliferative, invasive, migratory, and epithelial–mesenchymal transition abilities of triple-negative breast cancer cells

  • by Shuai Wang, Linfang Jin

  • May 18, 2026

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