RNF213 marks a regulatory T-cell subset associated with ulcerative colitis - Takeaways - MDSpire

RNF213 marks a regulatory T-cell subset associated with ulcerative colitis

  • By

  • Zhangqin Li

  • Jing Wu

  • Jiayi Yang

  • Lianyu Zhou

  • Lifang Chen

  • Youxu Ren

  • Yunxing Li

  • Ruijie Ma

  • Yinglei Miao

  • Jie Jia

  • Jiarong Miao

  • July 6, 2026

  • 0 min

Share

  • 1

    Ulcerative colitis (UC) is an autoimmune disease with unclear etiology and pathogenesis, necessitating the identification of new disease targets.

  • 2

    Five UC-specific ubiquitination biomarkers were identified, with RNF213 showing superior diagnostic performance in both training and validation cohorts.

  • 3

    RNF213 was found to be enriched in mucosal regulatory T cells (Tregs) from UC patients, indicating a potential link to inflammatory activity.

  • 4

    In-silico analysis suggested that RNF213-enriched Tregs may be associated with mitochondrial proton transport and ATP synthesis.

  • 5

    The study highlights RNF213 as a potential biomarker for UC, linked to Treg remodeling and immune dysregulation in the disease.

Original Source(s)

RNF213 marks a regulatory T-cell subset associated with ulcerative colitis

  • by Zhangqin Li, Jing Wu, Jiayi Yang, Lianyu Zhou, Lifang Chen, Youxu Ren, Yunxing Li, Ruijie Ma, Yinglei Miao, Jie Jia, Jiarong Miao

  • July 6, 2026

Related Content

The role of Astragalus membranaceus and its derivatives in digestive system diseases: reconstruction of immune tolerance

Correction: Incidence of Clostridium difficile infection and enteric pathogens in children with inflammatory bowel disease presenting with disease exacerbation

Malignancy as a rising contributor to mortality in patients with inflammatory bowel disease: a population-based epidemiological study