Survival Outcomes Following Preemptive vs Nonpreemptive Kidney Transplantation - Takeaways - MDSpire

Survival After Preemptive Versus Nonpreemptive Kidney Transplantation

By
Christie Rampersad
Ian Tatt Liew
Kuan Liu
Georgina L. Irish
Philip A. Clayton
Greg Knoll
Kyla Naylor
S. Joseph Kim
October 8, 2026

Jama Network Open

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1

Evidence for survival advantages after preemptive kidney transplantation remains uncertain because prior studies were observational and vulnerable to bias.
2

This US registry study used a target trial emulation to compare outcomes after preemptive and nonpreemptive transplantation.
3

The cohort included adults receiving a first kidney-alone transplant who were listed before dialysis and had an eGFR of 20 mL/min/1.73 m² or lower.
4

Analyses used left-truncated Cox models and inverse probability of treatment weighting to address lead-time bias and baseline confounding.
5

The primary outcome was all-cause mortality; secondary outcomes were all-cause graft failure, death-censored graft failure, and delayed graft function.

Original Source(s)

Jama Network Open

Survival Outcomes Following Preemptive vs Nonpreemptive Kidney Transplantation

by Christie Rampersad, Ian Tatt Liew, Kuan Liu, Georgina L. Irish, Philip A. Clayton, Greg Knoll, Kyla Naylor, S. Joseph Kim
October 8, 2026

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