Remimazolam-based anesthesia in sepsis patients: a retrospective cohort study of hemodynamic stability and postoperative outcomes

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Remimazolam-based anesthesia was associated with lower Vasopressor-Inotrope Score at ICU admission compared to propofol/volatile anesthesia.
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Patients receiving remimazolam had shorter ICU and hospital lengths of stay compared to those receiving propofol/volatile anesthesia.
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In-hospital mortality was lower in the remimazolam group, indicating improved postoperative outcomes.
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Remimazolam demonstrated more favorable intraoperative hemodynamics, including systolic blood pressure and heart rate trajectories.
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The study supports further prospective trials to evaluate the causality of remimazolam's benefits in septic surgical patients.

Frontiers In Medicine

by Hyunyoung Seong, Sejong Jin, Yeon Jae Song, Woohyun Park, Hyun Ah Lee, Jang Eun Cho
July 1, 2026

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