Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus - Takeaways - MDSpire

Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus

  • By

  • Rachel MacCann

  • Junhui Li

  • Alejandro Abner Garcia Leon

  • Riya Negi

  • Dana Alalwan

  • Willard Tinago

  • Padraig McGettrick

  • Aoife G Cotter

  • Alan Landay

  • Caroline Sabin

  • Paul W O’Toole

  • Patrick W G Mallon

  • for the Understanding the Pathology of Comorbid Disease in HIV-Infected Individuals (HIV UPBEAT) Study Group

  • Padraig McGettrick

  • Elena Alvarez Barco

  • Willard Tinago

  • Alejandro Garcia Leon

  • Aoife McDermott

  • Tara McGinty

  • Aoife G Cotter

  • Alan Macken

  • Patrick W G Mallon

  • Eoin Kavanagh

  • Geraldine McCarthy

  • Gerard Sheehan

  • John Lambert

  • William Powderly

  • Juliet Compston

  • Caroline Sabin

  • January 24, 2025

  • 0 min

Share

  • 1

    Chronic HIV infection is linked to systemic inflammation and altered gut microbiota, contributing to increased cardiovascular disease risk.

  • 2

    Individuals with HIV show significant differences in gut microbiome β-diversity compared to those without HIV, affecting cardiovascular health.

  • 3

    Specific gut bacteria, such as Bifidobacterium pseudocatenulatum, correlate with lower plaque burden, while Ruminococcus bromii is linked to higher plaque burden.

  • 4

    Depletion of short-chain fatty acid-producing bacteria is associated with immune activation and metabolic disorders in people living with HIV.

  • 5

    Understanding gut microbiome interactions with inflammation in HIV may help identify individuals at higher risk for cardiovascular diseases.

Original Source(s)

Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus

  • by Rachel MacCann, Junhui Li, Alejandro Abner Garcia Leon, Riya Negi, Dana Alalwan, Willard Tinago, Padraig McGettrick, Aoife G Cotter, Alan Landay, Caroline Sabin, Paul W O’Toole, Patrick W G Mallon, for the Understanding the Pathology of Comorbid Disease in HIV-Infected Individuals (HIV UPBEAT) Study Group, Padraig McGettrick, Elena Alvarez Barco, Willard Tinago, Alejandro Garcia Leon, Aoife McDermott, Tara McGinty, Aoife G Cotter, Alan Macken, Patrick W G Mallon, Eoin Kavanagh, Geraldine McCarthy, Gerard Sheehan, John Lambert, William Powderly, Juliet Compston, Caroline Sabin

  • January 24, 2025

Related Content

The Relationship Between Microbiota and Systemic Lupus Erythematosus: Insights into Mechanisms, Diagnostic Approaches, and Treatment Innovations

The Influence of Gut Microbiota on Guillain-Barré Syndrome: Investigating Microbial Metabolites, Biomarkers, and Novel Treatment Approaches

Insights from Multi-Omics on Maternal-Fetal Immune Tolerance in Recurrent Pregnancy Loss: Mechanisms, Integration Challenges, and Clinical Implications