Retrospective analysis of the clinical efficacy of topical hyaluronic acid in promoting skin recovery and reducing inflammatory reactions after fractional laser treatment - Takeaways - MDSpire
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Evaluation of the Clinical Effectiveness of Topical Hyaluronic Acid for Enhancing Skin Healing and Mitigating Inflammatory Responses Following Fractional Laser Therapy

  • By

  • Chungwen Yen

  • Tsean Yen

  • May 5, 2026

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  • 1

    Topical hyaluronic acid significantly shortens erythema disappearance and scab shedding times after fractional laser treatment.

  • 2

    Patients using hyaluronic acid showed lower serum levels of inflammatory markers IL-6 and TNF-α at postoperative days 7 and 14.

  • 3

    The hyaluronic acid group had improved skin moisture content and reduced transepidermal water loss compared to the routine care group.

  • 4

    Multivariate regression analysis confirmed hyaluronic acid as an independent factor for faster skin recovery and lower inflammation.

  • 5

    No significant differences were found in blood routine, liver/kidney function, or adverse reactions between the two patient groups.

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