Gut microbiota induces immune-related alterations in gene expression, RNA methylation, and metabolism in glioblastoma revealed by single-cell and spatial multi-omics - Takeaways - MDSpire

Gut microbiota induces immune-related alterations in gene expression, RNA methylation, and metabolism in glioblastoma revealed by single-cell and spatial multi-omics

  • By

  • Mingcong Chen

  • Xiang Wang

  • Gang Peng

  • Lihe Jiang

  • Hao Liang

  • Ping Cui

  • July 15, 2026

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  • 1

    Gut microbiota disruption via antibiotics alters gene expression in glioma, notably reducing Epha6 and increasing Tead1.

  • 2

    Metabolomic profiling shows reduced methionine levels in gliomas of antibiotic-treated mice, linking gut-derived metabolites to epigenetic regulation.

  • 3

    Single-cell RNA sequencing reveals increased AC-like cells and disrupted intercellular communication in gliomas following antibiotic treatment.

  • 4

    The study highlights the interplay between gut microbiota, immune signaling, and epigenetic modifications in glioma progression.

  • 5

    Findings suggest the EPHA pathway as a potential biomarker for immune-mediated modulation of glioma tumor progression.

Original Source(s)

Gut microbiota induces immune-related alterations in gene expression, RNA methylation, and metabolism in glioblastoma revealed by single-cell and spatial multi-omics

  • by Mingcong Chen, Xiang Wang, Gang Peng, Lihe Jiang, Hao Liang, Ping Cui

  • July 15, 2026

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