Identification of succinylation-related genes in bladder cancer: integration of single-cell and transcriptomic data - Takeaways - MDSpire

Identification of succinylation-related genes in bladder cancer: integration of single-cell and transcriptomic data

  • By

  • Jiajian Yang

  • Zhengyao You

  • Haojie Mo

  • Jinxian Pu

  • Gang Shen

  • Zhijun Miao

  • May 15, 2026

  • 0 min

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  • 1

    This study identified KCTD16, CD3D, and GSDMB as prognostic succinylation-related genes in bladder cancer.

  • 2

    A prognostic risk model incorporating these genes and clinical factors demonstrated robust predictive accuracy for bladder cancer outcomes.

  • 3

    High-risk bladder cancer patients exhibited enhanced immune evasion and an inflamed yet dysfunctional tumor microenvironment.

  • 4

    Single-cell analysis revealed key roles of epithelial cells, T cells, and fibroblasts in the tumor microenvironment.

  • 5

    Knockdown of GSDMB and KCTD16 promoted T24 cell proliferation, indicating their potential tumor-suppressive roles.

Original Source(s)

Identification of succinylation-related genes in bladder cancer: integration of single-cell and transcriptomic data

  • by Jiajian Yang, Zhengyao You, Haojie Mo, Jinxian Pu, Gang Shen, Zhijun Miao

  • May 15, 2026

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