The Impact of Estrogen Deficiency on Liver Metabolism: Implications for Hormone Replacement Therapy - Takeaways - MDSpire
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Effects of Estrogen Shortage on Hepatic Metabolism: Considerations for Hormone Replacement Therapy

  • By

  • Jiawen Dong

  • Kaitlyn M J H Dennis

  • Radha Venkatakrishnan

  • Leanne Hodson

  • Jeremy W Tomlinson

  • June 16, 2025

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  • 1

    Metabolic dysfunction-associated steatotic liver disease (MASLD) affects 1 in 3 individuals globally and is the most common chronic liver condition.

  • 2

    The prevalence of MASLD significantly increases in women after menopause, often surpassing rates seen in men.

  • 3

    Estrogen deficiency at menopause is strongly linked to the development and progression of MASLD in women.

  • 4

    Current clinical studies underrepresent women over 50, highlighting the need for tailored treatment strategies for MASLD.

  • 5

    The impact of hormone replacement therapy (HRT) on MASLD in postmenopausal women remains poorly studied despite its rising use.

Original Source(s)

The Impact of Estrogen Deficiency on Liver Metabolism: Implications for Hormone Replacement Therapy

  • by Jiawen Dong, Kaitlyn M J H Dennis, Radha Venkatakrishnan, Leanne Hodson, Jeremy W Tomlinson

  • June 16, 2025

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