HuBIE: The human blood immunome encyclopedia of TCRs and BCRs in bloodstream infections and cancer - Takeaways - MDSpire

HuBIE: The human blood immunome encyclopedia of TCRs and BCRs in bloodstream infections and cancer

  • By

  • Vahid Akbari

  • Alexandra Morgan

  • Michie Yasuda

  • Ulrich Schlecht

  • Sylvie McNamara

  • Hosseinali Asgharian

  • Christopher Tam

  • Rena Adachi

  • Elisa Contreras

  • Zhipei Gracie Du

  • Sandra Siemann

  • Hahn Zhao

  • Jeyashree Ashok Balasubramanian

  • Diane Balallo

  • Devanshee Sanghvi

  • Tarini Shankar

  • Sanjucta Dutta

  • Stefan Riedel

  • Stefanie Mattson

  • Daniel Burukhin

  • Florian Rubelt

  • Sowmi Utiramerur

  • Dinesh Kumar

  • Hamid Mirebrahim

  • Ramy Arnaout

  • June 18, 2026

  • 0 min

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  • 1

    HuBIE is a comprehensive resource featuring immune-repertoire data from 2,614 samples across diverse cancer types and bloodstream infections.

  • 2

    The study utilized Roche’s immunoPETE platform for simultaneous sequencing of TCR and BCR heavy chains, enhancing immune repertoire profiling.

  • 3

    Significant differences in TCR and BCR composition were observed across ethnic groups, with age-related variations in repertoire diversity.

  • 4

    Greater immunological diversity was linked to improved survival rates among elderly participants, highlighting its clinical relevance.

  • 5

    HuBIE supports personalized immunotherapy research and the development of diagnostics and prognostics through extensive clinical metadata.

Original Source(s)

HuBIE: The human blood immunome encyclopedia of TCRs and BCRs in bloodstream infections and cancer

  • by Vahid Akbari, Alexandra Morgan, Michie Yasuda, Ulrich Schlecht, Sylvie McNamara, Hosseinali Asgharian, Christopher Tam, Rena Adachi, Elisa Contreras, Zhipei Gracie Du, Sandra Siemann, Hahn Zhao, Jeyashree Ashok Balasubramanian, Diane Balallo, Devanshee Sanghvi, Tarini Shankar, Sanjucta Dutta, Stefan Riedel, Stefanie Mattson, Daniel Burukhin, Florian Rubelt, Sowmi Utiramerur, Dinesh Kumar, Hamid Mirebrahim, Ramy Arnaout

  • June 18, 2026

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