Knee OA Pain: Inulin vs Physiotherapy Effects Prebiotic supplementation and physiotherapy show distinct and complementary effects on functional and pain sensitivity outcomes. By Kathryn Wighton March 30, 2026 3 min Conexiant Share Summary Takeaways Listen Insight Report Clinical Scorecard Quiz Poll 1 Inulin and physiotherapy-supported exercise each significantly reduced pain in knee osteoarthritis patients over 6 weeks. 2 No synergistic effect was observed when combining inulin and physiotherapy-supported exercise interventions. 3 Inulin improved grip strength and increased pressure pain thresholds, while physiotherapy improved sit-to-stand and timed up-and-go performance. 4 Dropout rates were lower in the inulin group compared to the physiotherapy-supported exercise group. 5 The study suggests integrating dietary interventions with pharmacologic treatments for a holistic approach to osteoarthritis management.