Influence of Cardiovascular and Metabolic Comorbidities on the Severity and Outcomes of Hospital-Acquired Sepsis in ICU Patients: A Case-Control Analysis

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Sepsis is a leading cause of global mortality, accounting for 19.7% of deaths, with significant regional variations in incidence.
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The study investigates the impact of cardiovascular and metabolic comorbidities on the severity of hospital-acquired sepsis in ICU patients.
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Inflammatory markers like PCT, IL-6, IL-10, and TNF-α are crucial for understanding the inflammatory profile in sepsis patients.
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Septic shock is associated with chronic cardiovascular issues and a high mortality rate, particularly in patients with pre-existing conditions.
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The research aims to provide insights into risk stratification and inflammatory burden in sepsis patients from an underrepresented population.

Bmc Infectious Diseases

by Amrita Roy, Vignesh Krishnasamy, Sourabh Mitra, Sudip Banerjee, Tapan Kumar Dutta, Nachimuthu Senthil Kumar, Swagnik Roy
February 2, 2026

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