The role and therapeutic prospects of intercellular communication and RNA m6A modification in radiation-induced liver injury - Takeaways - MDSpire

The role and therapeutic prospects of intercellular communication and RNA m6A modification in radiation-induced liver injury

  • By

  • Huicong Yan

  • Yuhang Wang

  • Cunyang Guo

  • Yifei Du

  • Fangqi Tian

  • Ping Xu

  • July 7, 2026

  • 0 min

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  • 1

    Radiation-induced liver injury (RILI) is a significant complication of radiotherapy, with incidence rates ranging from 6% to 66% based on radiation dose.

  • 2

    RILI can manifest in acute and chronic phases, with acute symptoms appearing 2 weeks to 3 months post-radiation and chronic issues developing over several months to years.

  • 3

    Ionizing radiation alters the m6A modification landscape of hepatic RNA, disrupting hepatocyte homeostasis and intercellular communication.

  • 4

    Cytokine release and immune cell interactions play crucial roles in the progression of RILI, amplifying pro-inflammatory and profibrotic signaling.

  • 5

    Understanding the interplay between intercellular communication and m6A modification is essential for developing targeted therapies for RILI.

Original Source(s)

The role and therapeutic prospects of intercellular communication and RNA m6A modification in radiation-induced liver injury

  • by Huicong Yan, Yuhang Wang, Cunyang Guo, Yifei Du, Fangqi Tian, Ping Xu

  • July 7, 2026

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