TcdB From Hypervirulent Clostridioides difficile Induces Neuronal Loss and Neurotransmitter Alterations in the Intrinsic Enteric Nervous System - Takeaways - MDSpire
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Impact of TcdB from Hypervirulent Clostridioides difficile on Neuronal Integrity and Neurotransmitter Dynamics in the Enteric Nervous System

  • By

  • Kai Zhang

  • Qi Zhou

  • Hanyang Gu

  • Ming Yang

  • Xinghao Lin

  • Mengjie Wang

  • Huaqian Zhai

  • Feng Zhang

  • Yongneng Luo

  • Linjie Chen

  • Shuangshuang Wan

  • Yu Chen

  • Wei Chen

  • Dazhi Jin

  • Hui Hu

  • October 14, 2024

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  • 1

    Clostridioides difficile infection (CDI) is a leading cause of intestinal infections, with significant morbidity and mortality in developed nations.

  • 2

    Toxin B variant (TcdB2) from hypervirulent C difficile directly induces cytopathic effects on enteric neurons in vitro and in vivo.

  • 3

    Increased expression of choline acetyltransferase and neural nitric oxide synthase occurs in colonic neurons before cytopathic changes from TcdB2.

  • 4

    TcdB2 not only causes neuronal loss but also alters neurotransmitter composition in the enteric nervous system during CDI.

  • 5

    The study highlights the need to further explore the effects of CDI on intrinsic enteric neurons and their role in intestinal function.

Original Source(s)

TcdB From Hypervirulent Clostridioides difficile Induces Neuronal Loss and Neurotransmitter Alterations in the Intrinsic Enteric Nervous System

  • by Kai Zhang, Qi Zhou, Hanyang Gu, Ming Yang, Xinghao Lin, Mengjie Wang, Huaqian Zhai, Feng Zhang, Yongneng Luo, Linjie Chen, Shuangshuang Wan, Yu Chen, Wei Chen, Dazhi Jin, Hui Hu

  • October 14, 2024

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