Murray law-based quantitative flow ratio versus invasive fractional flow reserve in the left anterior descending coronary artery: impact of hydrostatic pressure correction and clinical implications - Takeaways - MDSpire

Murray law-based quantitative flow ratio versus invasive fractional flow reserve in the left anterior descending coronary artery: impact of hydrostatic pressure correction and clinical implications

  • By

  • András Ágoston

  • Ádám Piricsi

  • Bettina Szekeres

  • Mátyás Magyari

  • Balázs Tar

  • Gábor T. Szabó

  • Csaba A. Dézsi

  • Zsolt Piroth

  • Zoltán Ruzsa

  • Gábor G. Tóth

  • Shengxian Tu

  • Zsolt Kőszegi

  • June 17, 2026

  • 0 min

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  • 1

    Invasive fractional flow reserve (FFR) is the gold standard for guiding coronary revascularization, while quantitative flow ratio (QFR) offers a less invasive alternative.

  • 2

    The study involved 33 coronary lesions in the left anterior descending artery (LAD) to assess the impact of hydrostatic pressure correction on FFR measurements.

  • 3

    Hydrostatic correction increased the mean FFR from 0.78 to 0.81, aligning it closely with the mean μQFR of 0.81.

  • 4

    Pearson correlation between μQFR and FFR was high before and after correction, indicating strong agreement between the two methods.

  • 5

    Correcting FFR for hydrostatic pressure eliminated bias, improving the consistency of physiologic lesion assessments in the LAD.

Original Source(s)

Murray law-based quantitative flow ratio versus invasive fractional flow reserve in the left anterior descending coronary artery: impact of hydrostatic pressure correction and clinical implications

  • by András Ágoston, Ádám Piricsi, Bettina Szekeres, Mátyás Magyari, Balázs Tar, Gábor T. Szabó, Csaba A. Dézsi, Zsolt Piroth, Zoltán Ruzsa, Gábor G. Tóth, Shengxian Tu, Zsolt Kőszegi

  • June 17, 2026

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