CKAP2L promotes endometrial cancer progression by suppressing AKT ubiquitination and activating the PI3K/AKT signaling pathway - Takeaways - MDSpire

CKAP2L promotes endometrial cancer progression by suppressing AKT ubiquitination and activating the PI3K/AKT signaling pathway

  • By

  • Min Wei

  • Xuefei Bai

  • Lili Xi

  • Yongxiu Yang

  • May 20, 2026

  • 0 min

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  • 1

    CKAP2L is overexpressed in endometrial cancer (EC) tissues and correlates with aggressive tumor characteristics.

  • 2

    Knockdown of CKAP2L in EC models reduces cell proliferation, migration, invasion, and induces apoptosis.

  • 3

    CKAP2L stabilizes phosphorylated AKT by inhibiting its ubiquitination, thus activating the PI3K/AKT signaling pathway.

  • 4

    Overexpression of CKAP2L enhances malignant behaviors and actin cytoskeletal remodeling in EC cells.

  • 5

    CKAP2L may serve as a promising therapeutic target for improving treatment strategies in endometrial cancer.

Original Source(s)

CKAP2L promotes endometrial cancer progression by suppressing AKT ubiquitination and activating the PI3K/AKT signaling pathway

  • by Min Wei, Xuefei Bai, Lili Xi, Yongxiu Yang

  • May 20, 2026

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