Posterior minimal extrathyroidal extension as an independent risk factor for lateral lymph node metastasis in papillary thyroid carcinoma: a retrospective study based on a nomogram prediction model - Takeaways - MDSpire

Posterior minimal extrathyroidal extension as an independent risk factor for lateral lymph node metastasis in papillary thyroid carcinoma: a retrospective study based on a nomogram prediction model

  • By

  • Qi Zhao

  • Tong Li

  • Haochang Gu

  • Bin Lv

  • Nan Liu

  • June 17, 2026

  • 0 min

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  • 1

    Posterior minimal extrathyroidal extension (post-mETE) is significantly associated with a higher incidence of lateral lymph node metastasis (LLNM) in papillary thyroid carcinoma (PTC).

  • 2

    In a study of 1798 PTC patients, 21.75% were confirmed to have LLNM, highlighting the prevalence of this condition in thyroid cancer cases.

  • 3

    Six independent predictive factors for LLNM were identified, including maximum tumor diameter >1 cm and post-mETE, with specific odds ratios reported.

  • 4

    A predictive nomogram constructed in the study demonstrated good discrimination performance with an AUC of 0.850 for forecasting LLNM.

  • 5

    The findings assist in identifying occult lymph node metastases and may influence decisions regarding adjuvant radioactive iodine therapy and follow-up management.

Original Source(s)

Posterior minimal extrathyroidal extension as an independent risk factor for lateral lymph node metastasis in papillary thyroid carcinoma: a retrospective study based on a nomogram prediction model

  • by Qi Zhao, Tong Li, Haochang Gu, Bin Lv, Nan Liu

  • June 17, 2026

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