From the Journals

Psilocybin for Cocaine Use: Signal or Noise?

Pilot randomized study suggests possible benefit, but blinding concerns and limited generalizability complicate interpretation

1

Psilocybin was compared to diphenhydramine in treating cocaine use disorder.
2

40 patients participated in the study, which included a randomized trial.
3

The primary outcomes included cocaine-abstinent days and risk of relapse.
4

Significant limitations included blinding and small sample size.
5

Results showed psilocybin led to 29 more percentage points of abstinent days.
6

No serious adverse events were reported, yet mild events occurred.
7

The study's findings are considered preliminary and warrant further investigation.
8

Contingency management remains the most effective current treatment for stimulant use disorders.