Integrated approaches to target nuclear receptors for managing the co-morbidity of tuberculosis and diabetes - Takeaways - MDSpire

Integrated approaches to target nuclear receptors for managing the co-morbidity of tuberculosis and diabetes

  • By

  • Rashmi Arora

  • Nancy Ahuja

  • Saumyata Kumawat

  • Vipashu Kaushal

  • Rahul Sharma

  • Pawan Gupta

  • June 10, 2026

  • 0 min

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  • 1

    The dual epidemic of tuberculosis and type 2 diabetes mellitus presents significant global health challenges due to their interrelated pathophysiology.

  • 2

    Nuclear receptors Vdr, Rev-erbα, and Lxr were identified as key dysregulated targets in the comorbidity of TB and T2DM.

  • 3

    Combination therapy targeting these nuclear receptors significantly improved metabolic and infectious symptoms in a comorbid mouse model.

  • 4

    CT-treated mice showed reduced T2DM severity and lower TB disease burden compared to untreated controls.

  • 5

    Integrating metabolic and antimicrobial treatments via nuclear receptor modulation offers a novel strategy for managing TB-T2DM comorbidity.

Original Source(s)

Integrated approaches to target nuclear receptors for managing the co-morbidity of tuberculosis and diabetes

  • by Rashmi Arora, Nancy Ahuja, Saumyata Kumawat, Vipashu Kaushal, Rahul Sharma, Pawan Gupta

  • June 10, 2026

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